https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39572 Wed 27 Jul 2022 14:41:18 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42011 Wed 17 Aug 2022 09:18:20 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43181 40 000 participants. Included studies consistently reported an increased risk associated with greater numbers of intraindividual risk factors or unhealthy behaviours and the opposite for healthy or protective behaviours. A meta-analysis of studies with dementia outcomes resulted in a pooled relative risk for dementia of 1.20 (95% CI 1.04 to 1.39) for one risk factor, 1.65 (95% CI 1.40 to 1.94) for two and 2.21 (95% CI 1.78 to 2.73) for three or more, relative to no risk factors. Limitations include dependence on published results and variations in study outcome, cognitive assessment, length of follow-up and definition of risk factor exposure. Conclusions The strength of the reported associations, the consistency across studies and the suggestion of a dose response supports a need to keep modifiable risk factor exposure to a minimum and to avoid exposure to additional modifiable risks. Further research is needed to establish whether particular combinations of risk factors confer greater risk than others.]]> Wed 14 Sep 2022 08:23:22 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45793 Tue 14 Mar 2023 14:29:20 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:454 Thu 25 Jul 2013 09:09:49 AEST ]]>